modified hemoglobins in the absence of haptoglobin CD 163 is the macrophage scavenger receptor for native and chemically
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چکیده
word count: 198 text word count: 5414 Acknowledgments: We thank Dr. Stephanie Hiss (University of Bonn, Germany) for bovine Hp determination. Supported by the Foundation for Research at the Medical Faculty, University of Zurich (DS) and by the Hartmann-Muller Foundation (DS). Contributions: DJS: designed and performed research, wrote the paper; CAS: performed research; PWB: performed research; RAB: provided vital materials; GS: performed research; AIA: provided vital materials, wrote the paper; AS: wrote the paper. Blood First Edition Paper, prepublished online September 27, 2005; DOI 10.1182/blood-2005-03-1014 Copyright © 2005 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 21, 2013. bloodjournal.hematologylibrary.org From
منابع مشابه
CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.
CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist. We demonstrate that Hb interacts efficiently with CD163 in the absence of Hp. Not only is Hb internalized into an endosomal compartment by CD163 as a result of active receptor...
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تاریخ انتشار 2005